Catalog: YN6360
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$160.00
In stock
0
Add to cart
Collected
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Main Information
Target
RNASET2
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
WB
MW
28kD (Calculated)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
This antibody detects endogenous levels of RNase T2 at Human, Mouse
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Calculated)
28kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from human RNase T2
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Specificity:
This antibody detects endogenous levels of RNase T2 at Human, Mouse
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Gene Name:
RNASET2 RNASE6PL
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Protein Name:
Ribonuclease T2 (Ribonuclease 6)
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Function:
Ribonuclease that plays an essential role in innate immune response by recognizing and degrading RNAs from microbial pathogens that are subsequently sensed by TLR8 . Cleaves preferentially single-stranded RNA molecules between purine and uridine residues, which critically contributes to the supply of catabolic uridine and the generation of purine-2',3'-cyclophosphate-terminated oligoribonucleotides . In turn, RNase T2 degradation products promote the RNA-dependent activation of TLR8 . Plays also a key role in degradation of mitochondrial RNA and processing of non-coding RNA imported from the cytosol into mitochondria . Participates as well in degradation of mitochondrion-associated cytosolic rRNAs .
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Cellular Localization:
Secreted . Lysosome lumen . Endoplasmic reticulum lumen . Mitochondrion intermembrane space . Full-length RNASET2 is found in the endoplasmic reticulum while smaller RNASET2 proteolytic products are found in the lysosome fraction. .
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Tissue Expression:
Ubiquitous. Higher expression levels observed in the temporal lobe and fetal brain.
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Reference Citation({{totalcount}})
Catalog: YN6360
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$160.00
In stock
0
Add to cart
Collected
Collect
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