Catalog: YN5543
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$160.00
In stock
0
Add to cart
Collected
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Main Information
Target
KCNK10
Host Species
Rabbit
Reactivity
Human, Rat
Applications
WB, IHC, IF
MW
59kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:1000-2000; IHC 1:100-200; IF 1:50-200
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
KCNK10(TREK-2) protein(A237) detects endogenous levels of KCNK10(TREK-2)
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
59kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthetic Peptide of KCNK10 (TREK-2) AA range: 16-66
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Specificity:
KCNK10(TREK-2) protein(A237) detects endogenous levels of KCNK10(TREK-2)
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Gene Name:
KCNK10
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Protein Name:
Potassium channel subfamily K member 10 (Outward rectifying potassium channel protein TREK-2) (TREK-2 K(+) channel subunit)
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Other Name:
Potassium channel subfamily K member 10 ;
Outward rectifying potassium channel protein TREK-2 ;
TREK-2 K ;
+ ;
channel subunit ;
Outward rectifying potassium channel protein TREK-2 ;
TREK-2 K ;
+ ;
channel subunit ;
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Background:
potassium two pore domain channel subfamily K member 10(KCNK10) Homo sapiens The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations, and is stimulated strongly by arachidonic acid and to a lesser degree by membrane stretching, intracellular acidification, and general anaesthetics. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Sep 2008],
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Function:
Function:Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. Activated by arachidonic acid and other naturally occurring unsaturated free fatty acids.,similarity:Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.,tissue specificity:Abundantly expressed in pancreas and kidney and to a lower level in brain, testis, colon, and small intestine. Isoform b is strongly expressed in kidney (primarily in the proximal tubule) and pancreas, whereas isoform c is abundantly expressed in brain.,
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Cellular Localization:
Membrane ; Multi-pass membrane protein .
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Tissue Expression:
Abundantly expressed in pancreas and kidney and to a lower level in brain, testis, colon, and small intestine. Isoform b is strongly expressed in kidney (primarily in the proximal tubule) and pancreas, whereas isoform c is abundantly expressed in brain.
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Research Areas:
>>Gastric acid secretion
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Reference Citation({{totalcount}})
Catalog: YN5543
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$160.00
In stock
0
Add to cart
Collected
Collect
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