Cytoplasm. Cell membrane. Recruited to membranes upon activation by DAG.
show all
Tissue Expression:
Expressed by mast cells and their progenitors (at protein level). Specifically expressed in mononuclear leukocytes. Highly expressed in myeloid cells compared to lymphoid cells. Also detected in heart, skeletal muscle, spleen, liver, placenta and lung. Not detected in brain. Isoform 1 is the major isoform in normal individuals. Isoform 2 is more significantly expressed in a patient with asthma. Isoform 3 is more significantly expressed in a patient with asthma and a mastocytosis patient.
show all
Research Areas:
>>MAPK signaling pathway ;
>>Ras signaling pathway ;
>>Pathways in cancer