Synthesized peptide derived from human ZP3 AA range: 210-260

This antibody detects endogenous levels of ZP3 at Human/Mouse/Rat

ZP3 ZP3A ZP3B ZPC

ZP3

The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in primary binding and induction of the sperm acrosome reaction. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a C-terminal consensus furin cleavage site, and a transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. A variation in the last exon of this gene has previously served as the basis for an additional ZP3 locus; however, sequence and literature review reveals that there is only one full-length ZP3 locus in the human genome. Another locus encoding a bipartite transcript designated POMZP3 contains a duplication of the last four exons of ZP3, including the above described variation, and maps closely to this gene. [provided by RefSeq, Jul 2008],

Domain:The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.,Function:The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.,online information:Molecular chastity -Issue 93 of April 2008,PTM:N-glycosylated.,PTM:O-glycosylated; removal of O-linked glycans may play an important role in the post-fertilization block to polyspermy.,PTM:Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.,similarity:Belongs to the ZP domain family. ZPC subfamily.,similarity:Contains 1 ZP domain.,subunit:Polymers of ZP2 and ZP3 organized into long filaments cross-linked by ZP1 homodimers.,tissue specificity:Oocytes.,

[Processed zona pellucida sperm-binding protein 3]: Zona pellucida .; Cell membrane ; Single-pass type I membrane protein .