The main structural proteins of mammalian hair fiber are the hair keratins (see MIM 601077) and the keratin-associated proteins (KAPs), which form a rigid and resistant hair shaft through extensive disulfide bond crosslinking with the abundant cysteines of hair keratins (Shimomura et al., 2002 [PubMed 12228244]).[supplied by OMIM, Jan 2009],
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Function:
Function:In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.,similarity:Belongs to the KRTAP type 1 family.,subunit:Interacts with hair keratins.,tissue specificity:Expressed in the middle/upper portions of the hair cortex, in the region termed the keratogenous zone.,
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Cellular Localization:
keratin filament,
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Tissue Expression:
Expressed in the middle/upper portions of the hair cortex, in the region termed the keratogenous zone.