similarity:Belongs to the TMEM66 family.,tissue specificity:Highly expressed in macrophages.,
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Cellular Localization:
Endoplasmic reticulum membrane ; Single-pass type I membrane protein . Translocates to the endoplasmic reticulum-plasma membrane (ER-PM) region in a STIM1-dependent manner following cytosolic Ca(2+) elevation.; [Isoform 2]: Endoplasmic reticulum membrane; Single-pass type I membrane protein.