Synthesized peptide derived from part region of human protein

SYEP Polyclonal Antibody detects endogenous levels of protein.

EPRS GLNS PARS QARS QPRS PIG32

Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) (Cell proliferation-inducing gene 32 protein) [Includes: Glutamate--tRNA ligase (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (Prolyl-tRNA synthetase)]

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a multifunctional aminoacyl-tRNA synthetase that catalyzes the aminoacylation of glutamic acid and proline tRNA species. Alternative splicing has been observed for this gene, but the full-length nature and biological validity of the variant have not been determined. [provided by RefSeq, Jul 2008],

Catalytic activity:ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).,Catalytic activity:ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).,Caution:Was originally thought to be a glutaminyl-tRNA synthetase.,Domain:The WHEP-TRS domain is involved in RNA binding.,Function:Catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA.,sequence Caution:Contaminating sequence. Potential poly-A sequence.,sequence Caution:Sequencing errors.,similarity:Belongs to the class-I aminoacyl-tRNA synthetase family.,similarity:Contains 3 WHEP-TRS domains.,similarity:In the C-terminal section; belongs to the class-II aminoacyl-tRNA synthetase family.,similarity:In the N-terminal section; belongs to the class-I aminoacyl-tRNA synthetase family.,subunit:Component of the multisynthetase complex which is comprised of a bifunctional glutamyl-prolyl-tRNA synthetase, the monospecific isoleucyl, leucyl, glutaminyl, methionyl, lysyl, arginyl, and aspartyl-tRNA synthetases as well as three auxiliary proteins, p18, p48 and p43. Interacts with DUS2L.,

Cytoplasm, cytosol . Membrane ; Peripheral membrane protein . Translocates from cytosol to membranes upon phosphorylation at Ser-999. .

Bone marrow,Brain,Cervix carcinoma,Duodenum,Epithelium,Eye,Lung,Placenta,

>>Porphyrin metabolism ;
>>Aminoacyl-tRNA biosynthesis ;
>>Metabolic pathways ;
>>Biosynthesis of cofactors