This gene encodes a member of the netrin family of proteins, which function in various biological processes including axon guidance, tumorogenesis, and angiogenesis. Netrins are laminin-related proteins that have an N-terminal laminin-type domain, epidermal growth factor-like repeat domain, and a positively charged heparin-binding domain at the C-terminus. The protein encoded by this gene is involved in processes including neurite growth and migration, angiogenesis and mural cell adhesion to endothelial cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016],
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Function:
Function:May play an important role in neural, kidney and vascular development. Promotes neurite elongation from olfactory bulb explants.,similarity:Contains 1 laminin N-terminal domain.,similarity:Contains 1 NTR domain.,similarity:Contains 3 laminin EGF-like domains.,subcellular location:Major component.,subunit:May form a homodimer.,tissue specificity:Expressed in kidney, spleen, mammary gland, aorta, heart, ovary, prostate and fetal spleen.,
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Cellular Localization:
Secreted, extracellular space, extracellular matrix, basement membrane . Major component.
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Tissue Expression:
Expressed in kidney, spleen, mammary gland, aorta, heart, ovary, prostate and fetal spleen.