Catalog: YN2234
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
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Main Information
Target
LUM
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, ELISA
MW
37kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000; ELISA 1:5000-20000
Formulation
Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
Specificity
LUM Polyclonal Antibody detects endogenous levels of protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
37kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from human protein . at AA range: 30-110
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Specificity:
LUM Polyclonal Antibody detects endogenous levels of protein.
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Gene Name:
LUM LDC SLRR2D
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Protein Name:
Lumican (Keratan sulfate proteoglycan lumican) (KSPG lumican)
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Background:
This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. In these bifunctional molecules, the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican may regulate collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair. [provided by RefSeq, Jul 2008],
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Function:
developmental stage:Present in the extracellular matrix of human articular cartilage at all ages, although its abundance is far greater in the adult. In the adult cartilage lumican exists predominantly in a glycoprotein form lacking keratan sulfate, whereas the juvenile form of the molecule is a proteoglycan.,PTM:Sulfated on tyrosine residue(s).,similarity:Belongs to the small leucine-rich proteoglycan (SLRP) family. Class II subfamily.,similarity:Contains 12 LRR (leucine-rich) repeats.,subunit:Binds to laminin.,tissue specificity:Cornea and other tissues.,
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Cellular Localization:
Secreted, extracellular space, extracellular matrix .
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Tissue Expression:
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Research Areas:
>>Proteoglycans in cancer
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Reference Citation({{totalcount}})
Catalog: YN2234
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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