fibronectin leucine rich transmembrane protein 3(FLRT3) Homo sapiens This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. FLRTs may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. This gene is expressed in many tissues. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2010],
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Function:
Function:May have a function in cell adhesion and/or receptor signaling.,similarity:Contains 1 fibronectin type-III domain.,similarity:Contains 10 LRR (leucine-rich) repeats.,tissue specificity:Expressed in kidney, brain, pancreas, skeletal muscle, lung, liver, placenta, and heart.,
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Cellular Localization:
Cell membrane ; Single-pass membrane protein . Endoplasmic reticulum membrane . Cell junction, focal adhesion . Secreted . Cell projection, axon . Cell projection, growth cone membrane . Detected on dendritic punctae that colocalize in part with glutamaergic synapses, but not with GABAergic synapses. Proteolytic cleavage in the juxtamembrane region gives rise to a shedded ectodomain. .
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Tissue Expression:
Expressed in kidney, brain, pancreas, skeletal muscle, lung, liver, placenta, and heart.