This gene belongs to the guanine-binding protein (GBP) family, which includes interferon-induced proteins that can bind to guanine nucleotides (GMP, GDP and GTP). The encoded protein is a GTPase which hydrolyzes GTP, predominantly to GDP. The protein may play a role as a marker of squamous cell carcinomas. [provided by RefSeq, Jul 2013],
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Function:
Function:Binds GTP, GDP and GMP. Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product.,induction:By interferon gamma during macrophage activation.,similarity:Belongs to the GBP family.,
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Cellular Localization:
Cytoplasm . Cytoplasm, perinuclear region . Golgi apparatus membrane . Membrane; Lipid-anchor . Cytoplasmic vesicle . GBP2-GBP5 dimers localize to the Golgi apparatus. .