The protein encoded by this gene belongs to the ZIP family of zinc transporters that transport zinc into cells from outside, and play a crucial role in controlling intracellular zinc levels. Zinc is an essential cofactor for many enzymes and proteins involved in gene transcription, growth, development and differentiation. Mutations in this gene have been associated with autosomal dominant high myopia (MYP24). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014],
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Function:
Function:May play a role in polarized cells by carrying out serosal-to-mucosal zinc transport. Seems to play a central role in controlling organismal zinc status.,PTM:Glycosylated.,similarity:Belongs to the ZIP transporter (TC 2.A.5) family.,tissue specificity:Expressed in liver, kidney, pancreas, small intestine, colon, spleen, fetal liver and fetal kidney.,
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Cellular Localization:
Basolateral cell membrane ; Multi-pass membrane protein .
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Tissue Expression:
Expressed in liver, kidney, pancreas, small intestine, colon, spleen, fetal liver and fetal kidney.