Catalog: YN1295
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
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Main Information
Target
SH2D3
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
WB, ELISA
MW
94kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000; ELISA 1:5000-20000
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Specificity
SH2D3 Polyclonal Antibody detects endogenous levels of protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
94kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from part region of human protein
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Specificity:
SH2D3 Polyclonal Antibody detects endogenous levels of protein.
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Gene Name:
SH2D3C NSP3 UNQ272/PRO309/PRO34088
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Protein Name:
SH2 domain-containing protein 3C (Novel SH2-containing protein 3)
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Background:
This gene encodes an adaptor protein and member of a cytoplasmic protein family involved in cell migration. The encoded protein contains a putative Src homology 2 (SH2) domain and guanine nucleotide exchange factor-like domain which allows this signaling protein to form a complex with scaffolding protein Crk-associated substrate. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011],
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Function:
Function:Eph receptor-binding protein which may be a positive regulator of TCR signaling. Binding to BCAR1 is required to induce membrane ruffling and promote EGF-dependent cell migration.,similarity:Contains 1 Ras-GEF domain.,similarity:Contains 1 SH2 domain.,subcellular location:Associated with the membrane when EGF-stimulated. Found at ruffling membranes.,subunit:Interacts with PTK2B. Isoform 2 interacts with BCAR1/CAS and NEDD9/HEF1.,tissue specificity:Ubiquitously expressed.,
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Cellular Localization:
Cytoplasm . Cell membrane ; Peripheral membrane protein . Cell projection, axon . Cell projection, ruffle membrane . Associated with the membrane when EGF-stimulated (By similarity). Expressed at the cortical actin ring in B cells (By similarity). .; [Isoform 1]: Cell membrane ; Peripheral membrane protein .
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Tissue Expression:
[Isoform 1]: Ubiquitously expressed.
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Reference Citation({{totalcount}})
Catalog: YN1295
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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