Synthesized peptide derived from human protein . at AA range: 40-120

MUC7 Polyclonal Antibody detects endogenous levels of protein.

MUC7 MG2

Mucin-7 (MUC-7) (Apo-MG2) (Salivary mucin-7)

mucin 7, secreted(MUC7) Homo sapiens This gene encodes a small salivary mucin, which is thought to play a role in facilitating the clearance of bacteria in the oral cavity and to aid in mastication, speech, and swallowing. The central domain of this glycoprotein contains tandem repeats, each composed of 23 amino acids. This antimicrobial protein has antibacterial and antifungal activity. The most common allele contains 6 repeats, and some alleles may be associated with susceptibility to asthma. Alternatively spliced transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Oct 2014],

Disease:MUC7 alleles are associated with susceptibility to asthma [MIM:600807]. The MUC7*5 allele is rarer in the atopic asthmatics than in the atopic non-asthmatics. Comparison of all atopic individuals with all nonatopic shows no difference, while comparison of all asthmatic individuals with all non-asthmatic shows that the asthmatic group has reduced MUC7*5 frequency. The significantly lower frequency of the MUC7*5 allele in individuals with atopic asthma was explained by the possible association between alleles and different interactions with bacteria, since the glycosylated domain is thought to be responsible, at least in part, for the bacterial binding that allows bacteria to be cleared from the epithelial surfaces.,Function:May function in a protective capacity by promoting the clearance of bacteria in the oral cavity and aiding in mastication, speech, and swallowing. Binds P.aeruginosa pili.,polymorphism:The most common allele, MUC7*6, contains a tandem repeat domain comprising 6 repeats (shown here) each composed of 23 amino acids. These repeats are very similar but not identical. In a large cohort of 375 individuals from a variety of ethnic backgrounds, three different alleles were detected, MUC7*6 being the most common, in all populations studied, followed by MUC7*5 (5 repeats), with frequency varying from 0.05 in Africans to 0.22 in East Asians. MUC7*8 (8 repeats), a novel rare allele, was identified in 1 Northern European individual.,PTM:N- and O-glycosylated. Contains fucose, mannose, galactose, N-acetylglucosamine and N-acetylgalactosamine.,subunit:Monomer.,tissue specificity:Expressed in salivary gland tissues and only in those that contain mucous acinar cells (e.g. sublingual and submandibular glands) and not in salivary glands containing only serous acinar cells (e.g. parotid gland).,

Secreted .

>>Salivary secretion