This gene is a member of the carboxypeptidase A/B subfamily, and it is located in a cluster with three other family members on chromosome 7. Carboxypeptidases are zinc-containing exopeptidases that catalyze the release of carboxy-terminal amino acids, and are synthesized as zymogens that are activated by proteolytic cleavage. This gene could be involved in the histone hyperacetylation pathway. It is imprinted and may be a strong candidate gene for prostate cancer aggressiveness. [provided by RefSeq, Jul 2008],
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Function:
cofactor:Binds 1 zinc ion per subunit.,Function:Metalloprotease that could be involved in the histone hyperacetylation pathway.,induction:Up-regulated by inhibitors of histone dacetylation.,similarity:Belongs to the peptidase M14 family.,subunit:Interacts with LXN.,tissue specificity:Fetal expression in the adrenal gland, brain, heart, intestine, kidney, liver and lung. Except for fetal brain that shows no imprinting, expression was found preferentially from the maternal allele.,
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Cellular Localization:
Secreted .
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Tissue Expression:
Fetal expression in the adrenal gland, brain, heart, intestine, kidney, liver and lung. Except for fetal brain that shows no imprinting, expression was found preferentially from the maternal allele.