Members of the 1-acylglycerol-3-phosphate O-acyltransferase (EC 2.3.1.51) family, such as AGPAT7, catalyze the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA), a precursor in the biosynthesis of all glycerolipids. Both LPA and PA are involved in signal transduction (Ye et al., 2005 [PubMed 16243729]).[supplied by OMIM, May 2008],
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Function:
Caution:Was originally (PubMed:16243729) thought to be a lysophosphatidic acid acyltransferase based on sequence similarity but the mouse ortholog has been shown to be a lysophosphatidylcholine acyltransferase.,Function:Converts lysophosphatidylcholine (LPC) to phosphatidycholine in the presence of acyl-CoA.,pathway:Lipid metabolism; phospholipid metabolism.,similarity:Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.,tissue specificity:Widely expressed. Expressed in uterus, thymus, pancreas, skeletal muscle, bladder, stomach, lung and testis.,
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Cellular Localization:
Endoplasmic reticulum membrane ; Multi-pass membrane protein .