Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. The type II keratins are clustered in a region of chromosome 12q13. [provided by RefSeq, Jun 2009],
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Function:
developmental stage:Synthesized during maturation of epidermal keratinocytes.,Function:Probably contributes to terminal cornification.,miscellaneous:There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).,sequence Caution:Translated as Glu.,similarity:Belongs to the intermediate filament family.,subunit:Heterotetramer of two type I and two type II keratins.,