Catalog: YM8894
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
40μL
$190.00
3 weeks
0
Add to cart
Collected
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Main Information
Target
UPB1
Host Species
Rabbit
Reactivity
Human
Applications
WB, IHC, IP
MW
42kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:1000-5000; IHC 1:100-300; IP 1:50-100
Formulation
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Specificity
Endogenous
Purification
Protein A
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
MW(Observed)
42kD
Modification
Unmodified
Clonality
Monoclonal
Clone Number
PT0799R
Isotype
IgG,Kappa
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Antigen&Target Information
Specificity:
Endogenous
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Gene Name:
UPB1;BUP1
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Protein Name:
Beta-ureidopropionase;BUP-1;Beta-alanine synthase;N-carbamoyl-beta-alanine amidohydrolase;
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Other Name:
UPB1 ;
BUP1 ;
Beta-ureidopropionase ;
BUP-1 ;
Beta-alanine synthase ;
N-carbamoyl-beta-alanine amidohydrolase ;
BUP1 ;
Beta-ureidopropionase ;
BUP-1 ;
Beta-alanine synthase ;
N-carbamoyl-beta-alanine amidohydrolase ;
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Database Link:
Background:
This gene encodes a protein that belongs to the CN hydrolase family. Beta-ureidopropionase catalyzes the last step in the pyrimidine degradation pathway. The pyrimidine bases uracil and thymine are degraded via the consecutive action of dihydropyrimidine dehydrogenase (DHPDH), dihydropyrimidinase (DHP) and beta-ureidopropionase (UP) to beta-alanine and beta-aminoisobutyric acid, respectively. UP deficiencies are associated with N-carbamyl-beta-amino aciduria and may lead to abnormalities in neurological activity. [provided by RefSeq, Jul 2008]
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Function:
Catalyzes a late step in pyrimidine degradation (PubMed:22525402, PubMed:24526388). Converts N-carbamoyl-beta-alanine (3-ureidopropanoate) into beta-alanine, ammonia and carbon dioxide (PubMed:10415095, PubMed:10542323, PubMed:11508704, PubMed:22525402, PubMed:24526388, PubMed:29976570). Likewise, converts N-carbamoyl-beta-aminoisobutyrate (3-ureidoisobutyrate) into beta-aminoisobutyrate, ammonia and carbon dioxide (Probable). {ECO:0000269|PubMed:10415095, ECO:0000269|PubMed:10542323, ECO:0000269|PubMed:11508704, ECO:0000269|PubMed:22525402, ECO:0000269|PubMed:24526388, ECO:0000269|PubMed:29976570, ECO:0000305|PubMed:22525402, ECO:0000305|PubMed:24526388}.
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Cellular Localization:
Cytoplasm.
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Tissue Expression:
Detected in liver (at protein level). {ECO:0000269|PubMed:22525402}.
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Reference Citation({{totalcount}})
Catalog: YM8894
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
40μL
$190.00
3 weeks
0
Add to cart
Collected
Collect
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