Catalog: YM4928
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
40μL
$190.00
In stock
0
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Collected
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Main Information
Target
FLI1
Host Species
Mouse
Reactivity
Human, Mouse,
Applications
IHC, WB, IF, ELISA
MW
51kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
IHC 1:100-500; WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000
Formulation
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Specificity
This antibody detects endogenous levels of FLI1 and ERG protein.
Purification
Protein G
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
MW(Observed)
51kD
Modification
Unmodified
Clonality
Monoclonal
Clone Number
ABT-FLI1
Isotype
IgG1,Kappa
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from human FLI1 AA range: 300-400
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Specificity:
This antibody detects endogenous levels of FLI1 and ERG protein.
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Gene Name:
FLI1
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Protein Name:
Friend leukemia integration 1 transcription factor (Proto-oncogene Fli-1) (Transcription factor ERGB)
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Background:
This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t(11;22)(q24;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation involving this gene has also been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012],
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Function:
Disease:A chromosomal aberration involving FLI1 is a cause of Ewing sarcoma [MIM:133450]. Translocation t(11;22)(q24;q12) with EWS.,Function:Sequence-specific transcriptional activator. Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'.,miscellaneous:Located on a fragment of chromosome 11 flanked on the centromeric side by the acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation breakpoint and on the telomeric side by the Ewing- and neuroepithelioma-associated t(11;22) (q24;q12) breakpoint.,similarity:Belongs to the ETS family.,similarity:Contains 1 ETS DNA-binding domain.,similarity:Contains 1 PNT (pointed) domain.,subunit:Can form homodimers or heterodimers with ETV6/TEL1.,
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Cellular Localization:
Nuclear
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Tissue Expression:
Blood,Bone marrow,Lymph,Placenta,
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Research Areas:
>>Transcriptional misregulation in cancer
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Reference Citation({{totalcount}})
Catalog: YM4928
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
40μL
$190.00
In stock
0
Add to cart
Collected
Collect
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