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β I tubulin Mouse mAb

-YM3119

Main Information
Target

Tubulin β

Host Species

Mouse

Reactivity

Zebrafish

Applications

WB

MW

50kD (Observed)

Conjugate/Modification


Unmodified

Detailed Information
Recommended Dilution Ratio
WB 1:500-10000
Formulation
PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
Specificity
The antibody detects Zebrafish endgenousβ I tubulin proteins.
Purification
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
MW(Observed)
50kD
Modification
Unmodified
Clonality
Monoclonal
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Antigen&Target Information
Immunogen:
Synthetic Peptide of β I tubulin
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Specificity:
The antibody detects Zebrafish endgenousβ I tubulin proteins.
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Gene Name:
TUBB1
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Protein Name:
Tubulin beta-1 chain
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Other Name:
TUBB1 ;
Tubulin beta-1 chain ;
TUBB2A ;
TUBB2 ;
Tubulin beta-2A chain ;
TUBB2B ;
Tubulin beta-2B chain ;
TUBB4B ;
TUBB2C ;
Tubulin beta-4B chain ;
Tubulin beta-2 chain ;
Tubulin beta-2C chain ;
TUBB3 ;
TUBB4 ;
Tubulin beta-3 chain ;
Tubulin beta-4 chain ;
Tubulin beta-III ;
TUBB4A ;
TUBB4 ;
TUBB5 ;
Tubulin beta-4A chain ;
Tubulin 5 beta ;
Tubulin beta-4 chain ;
TUBB ;
TUBB5 ;
OK/SW-cl.56 ;
Tubulin beta chain ;
Tubulin beta-5 chain ;
TUBB6 ;
Tubulin beta-6 chain ;
TUBB8 ;
Tubulin beta-8 chain
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Database Link:
Organism Gene ID SwissProt
Human 81027;
Mouse 545486; A2AQ07;
Background:
This gene encodes a member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is specifically expressed in platelets and megakaryocytes and may be involved in proplatelet production and platelet release. A mutations in this gene is associated with autosomal dominant macrothrombocytopenia. Two pseudogenes of this gene are found on chromosome Y.[provided by RefSeq, Jul 2010],
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Function:
Function:Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain.,similarity:Belongs to the tubulin family.,subunit:Dimer of alpha and beta chains.,
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Cellular Localization:
Cytoplasm, cytoskeleton .
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Tissue Expression:
Hematopoietic cell-specific. Major isotype in leukocytes, where it represents 50% of all beta-tubulins.
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Research Areas:
>>Phagosome ;
>>Gap junction ;
>>Alzheimer disease ;
>>Parkinson disease ;
>>Amyotrophic lateral sclerosis ;
>>Huntington disease ;
>>Prion disease ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Pathogenic Escherichia coli infection ;
>>Salmonella infection
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