Recombinant human HtrA2/Omi protein.

This antibody detects endogenous levels of HtrA2/Omi and does not cross-react with related proteins.

HtrA2/Omi

High temperature requirement protein A2 ;
HTRA 2 ;
HtrA like serine protease ;
HtrA serine peptidase 2 ;
HtrA, E. coli, homolog of, 2 ;
HtrA2 ;
HTRA2_HUMAN ;
mitochondrial ;
Omi stress regulated endoprotease ;
Omi stress-regulated endoprotease ;
PARK 13 ;
PARK13 ;
Protease serin

This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to the mitochondria with release to the cytosol following apoptotic stimulus. The protein is thought to induce apoptosis by binding the apoptosis inhibitory protein baculoviral IAP repeat-containing 4. Nuclear localization of this protein has also been observed. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016],

Catalytic activity:Cleavage of non-polar aliphatic amino-acids at the P1 position, with a preference for Val, Ile and Met. At the P2 and P3 positions, Arg is selected most strongly with a secondary preference for other hydrophilic residues.,Disease:Defects in HTRA2 are the cause of Parkinson disease type 13 (PARK13) [MIM:610297, 168600]. Parkinson disease (PD) is a complex, multifactorial disorder that typically manifests after the age of 50 years, although early-onset cases (before 50 years) are known. PD generally arises as a sporadic condition but is occasionally inherited as a simple mendelian trait. Although sporadic and familial PD are very similar, inherited forms of the disease usually begin at earlier ages and are associated with atypical clinical features. PD is characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain.,Domain:The mature N-terminus is involved in the interaction with XIAP.,Domain:The PDZ domain mediates interaction with MXI2.,Function:Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Isoform 2 seems to be proteolytically inactive.,PTM:Autoproteolytically activated.,similarity:Belongs to the peptidase S1B family.,similarity:Contains 1 PDZ (DHR) domain.,subcellular location:Predominantly present in the intermembrane space. Released into the cytosol following apoptotic stimuli, such as UV treatment, and stimulation of mitochondria with caspase-8 truncated BID/tBID.,subunit:Homotrimer. Interacts with MXI2. The mature protein, but not the precursor, binds to BIRC2, BIRC3 and XIAP.,tissue specificity:Isoform 1 is ubiquitous; isoform 2 is expressed predominantly in the kidney, colon and thyroid.,

Mitochondrion intermembrane space. Mitochondrion membrane ; Single-pass membrane protein . Predominantly present in the intermembrane space. Released into the cytosol following apoptotic stimuli, such as UV treatment, and stimulation of mitochondria with caspase-8 truncated BID/tBID.; [Isoform 1]: Endoplasmic reticulum .

[Isoform 1]: Ubiquitously expressed.

>>Apoptosis ;
>>Apoptosis - multiple species ;
>>Parkinson disease ;
>>Pathways of neurodegeneration - multiple diseases