Catalog: YM1353
Size
Price
Status
Qty.
200μL
$450.00
3 weeks
0
100μL
$280.00
3 weeks
0
40μL
$160.00
3 weeks
0
Add to cart
Collected
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Main Information
Target
CHD4
Host Species
Mouse
Reactivity
Human
Applications
WB, CoIP
MW
260kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:1000; IP 1:50-200
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
This antibody detects endogenous levels of CHD4 and does not cross-react with related proteins.
Purification
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
MW(Observed)
260kD
Modification
Unmodified
Clonality
Monoclonal
Clone Number
8B8
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Antigen&Target Information
Immunogen:
Purified recombinant human CHD4 protein fragments expressed in E.coli.
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Specificity:
This antibody detects endogenous levels of CHD4 and does not cross-react with related proteins.
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Gene Name:
CHD4
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Other Name:
CHD4 ;
Chromodomain-helicase-DNA-binding protein 4 ;
CHD-4 ;
ATP-dependent helicase CHD4 ;
Mi-2 autoantigen 218 kDa protein ;
Mi2-beta
Chromodomain-helicase-DNA-binding protein 4 ;
CHD-4 ;
ATP-dependent helicase CHD4 ;
Mi-2 autoantigen 218 kDa protein ;
Mi2-beta
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Background:
The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. Somatic mutations in this gene are associated with serous endometrial tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014],
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Function:
Disease:One of the main antigens reacting with anti-MI-2 positive sera of dermatomyositis.,Function:Probable transcription regulator.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the SNF2/RAD54 helicase family.,similarity:Contains 1 helicase ATP-binding domain.,similarity:Contains 1 helicase C-terminal domain.,similarity:Contains 2 chromo domains.,similarity:Contains 2 PHD-type zinc fingers.,subunit:Central component of the nucleosome remodeling and histone deacetylase (NuRD) repressor complex. Interacts with TRIM27. Part of a complex containing ATR and HDAC2. Interacts with KLF1; the interaction depends on sumoylation of KLF1, and leads to its transcriptional repression.,
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Cellular Localization:
Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Associates with centrosomes in interphase. .
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Tissue Expression:
Epithelium,Pancreas,Skin,Uterus,
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Research Areas:
>>Human papillomavirus infection ;
>>Viral carcinogenesis
>>Viral carcinogenesis
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YM1353
Size
Price
Status
Qty.
200μL
$450.00
3 weeks
0
100μL
$280.00
3 weeks
0
40μL
$160.00
3 weeks
0
Add to cart
Collected
Collect
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