Purified recombinant human TBLR1 protein fragments expressed in E.coli.

This antibody detects endogenous levels of TBLR1 and does not cross-react with related proteins.

tbl1xr1

C21 ;
DC42 ;
F box like/WD repeat containing protein TBL1XR1 ;
F-box-like/WD repeat-containing protein TBL1XR1 ;
FLJ12894 ;
IRA1 ;
Nuclear receptor corepressor/HDAC3 complex subunit ;
Nuclear receptor corepressor/HDAC3 complex subunit TBLR1 ;
TBL1 related protein 1 ;
TBL1-related protein 1 ;
TBL1R_HUMAN ;
TBL1XR1 ;
Transducin ;
beta ;
like 1 X linked receptor 1 ;
Transducin beta like 1X related protein 1 ;
Transducin beta-like 1X-related protein 1.

This gene is a member of the WD40 repeat-containing gene family and shares sequence similarity with transducin (beta)-like 1X-linked (TBL1X). The protein encoded by this gene is thought to be a component of both nuclear receptor corepressor (N-CoR) and histone deacetylase 3 (HDAC 3) complexes, and is required for transcriptional activation by a variety of transcription factors. Mutations in these gene have been associated with some autism spectrum disorders, and one finding suggests that haploinsufficiency of this gene may be a cause of intellectual disability with dysmorphism. Mutations in this gene as well as recurrent translocations involving this gene have also been observed in some tumors. [provided by RefSeq, Mar 2016],

Domain:The F-box-like domain is related to the F-box domain, and apparently displays the same function as component of ubiquitin E3 ligase complexes.,Function:F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteosomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence Caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the WD repeat EBI family.,similarity:Contains 1 F-box-like domain.,similarity:Contains 1 LisH domain.,similarity:Contains 8 WD repeats.,subunit:Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1XR1, CORO2A and GPS2. Probable component of some E3 ubiquitin ligase complex. Interacts with histones H2B and H4.,tissue specificity:Ubiquitous.,

Nucleus .

>>Wnt signaling pathway