Purified recombinant fragment of human TH-POK expressed in E. Coli.

TH-POK Monoclonal Antibody detects endogenous levels of TH-POK protein.

ZBTB7B

Zinc finger and BTB domain-containing protein 7B

ZBTB7B ;
ZBTB15 ;
ZFP67 ;
ZNF857B ;
Zinc finger and BTB domain-containing protein 7B ;
Krueppel-related zinc finger protein cKrox ;
hcKrox ;
T-helper-inducing POZ/Krueppel-like factor ;
Zinc finger and BTB domain-containing protein 15 ;
Zinc finger

This gene encodes a zinc finger-containing transcription factor that acts as a key regulator of lineage commitment of immature T-cell precursors. It is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. It also functions as a transcriptional repressor of type I collagen genes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012],

Function:Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes.,similarity:Contains 1 BTB (POZ) domain.,similarity:Contains 4 C2H2-type zinc fingers.,

Nucleus .

Salivary gland,Skin fibroblast,Uterus,