Catalog: YM0476
Size
Price
Status
Qty.
200μL
$600.00
3 weeks

0

100μL
$350.00
3 weeks

0

50μL
$210.00
3 weeks

0

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Collected

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Main Information
Target

Nkx-2.5

Host Species

Mouse

Reactivity

Human

Applications

WB, ELISA

MW

35kD (Calculated)

Conjugate/Modification


Unmodified

Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
Nkx-2.5 Monoclonal Antibody detects endogenous levels of Nkx-2.5 protein.
Purification
Affinity purification
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
MW(Calculated)
35kD
Modification
Unmodified
Clonality
Monoclonal
Clone Number
6G4
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Antigen&Target Information
Immunogen:
Purified recombinant fragment of human Nkx-2.5 expressed in E. Coli.
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Specificity:
Nkx-2.5 Monoclonal Antibody detects endogenous levels of Nkx-2.5 protein.
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Gene Name:
NKX2-5
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Protein Name:
Homeobox protein Nkx-2.5
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Other Name:
NKX2-5 ;
CSX ;
NKX2.5 ;
NKX2E ;
Homeobox protein Nkx-2.5 ;
Cardiac-specific homeobox ;
Homeobox protein CSX ;
Homeobox protein NK-2 homolog E
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Database Link:
Organism Gene ID SwissProt
Human 1482; P52952;
Mouse P42582;
Background:
This gene encodes a homeobox-containing transcription factor. This transcription factor functions in heart formation and development. Mutations in this gene cause atrial septal defect with atrioventricular conduction defect, and also tetralogy of Fallot, which are both heart malformation diseases. Mutations in this gene can also cause congenital hypothyroidism non-goitrous type 5, a non-autoimmune condition. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009],
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Function:
Disease:Defects in NKX2-5 are a cause of tetralogy of Fallot (TOF) [MIM:187500]. TOF is a congenital heart anomaly which consists of pulmonary stenosis, ventricular septal defect, dextroposition of the aorta (aorta is on the right side instead of the left) and hypertrophy of the right ventricle. This condition results in a blue baby at birth due to inadequate oxygenation. Surgical correction is emergent.,Disease:Defects in NKX2-5 are the cause of atrial septal defect with atrioventricular conduction defects (ASD-AVCD) [MIM:108900]. ASD-AVCD is a congenital heart malformation characterized by atrioventricular conduction defects and incomplete closure of the wall between the atria resulting in blood flow from the left to the right atria.,Disease:Defects in NKX2-5 are the cause of congenital hypothyroidism non-goitrous type 5 (CHNG5) [MIM:225250]. CHNG5 is a non-autoimmune condition characterized by resistance to thyroid-stimulating hormone (TSH) leading to increased levels of plasma TSH and low levels of thyroid hormone. CHNG5 presents variable severity depending on the completeness of the defect. Most patients are euthyroid and asymptomatic, with a normal sized thyroid gland. Only a subset of patients develop hypothyroidism and present a hypoplastic thyroid gland.,Function:Implicated in commitment to and/or differentiation of the myocardial lineage. Acts as a transcriptional activator of ANF in cooperation with GATA4.,online information:Congenital heart disease website,similarity:Belongs to the NK-2 homeobox family.,similarity:Contains 1 homeobox DNA-binding domain.,subunit:Interacts with HIPK1 and HIPK2, but not HIPK3. Interacts with the C-terminal zinc finger of GATA4 through its homeobox domain. Also interacts with JARID2 which represses its ability to activate transcription of ANF. Interacts with FBLIM1.,tissue specificity:Expressed only in the heart.,
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Cellular Localization:
Nucleus .
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Tissue Expression:
Catalog: YM0476
Size
Price
Status
Qty.
200μL
$600.00
3 weeks

0

100μL
$350.00
3 weeks

0

50μL
$210.00
3 weeks

0

Add to cart

Collected

Collect

Customized Service

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