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Catalog: YM0374
Size
Price
Status
Qty.
200μL
$600.00
3 weeks

0

100μL
$350.00
3 weeks

0

50μL
$210.00
3 weeks

0

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Main Information
Target

IMP-3

Host Species

Mouse

Reactivity

Human

Applications

WB, IHC, IF, ELISA

MW

64kD (Calculated)

Conjugate/Modification


Unmodified

Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000; IF 1:50-200
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
IMP-3 Monoclonal Antibody detects endogenous levels of IMP-3 protein.
Purification
Affinity purification
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
MW(Calculated)
64kD
Modification
Unmodified
Clonality
Monoclonal
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Antigen&Target Information
Immunogen:
Purified recombinant fragment of human IMP-3 expressed in E. Coli.
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Specificity:
IMP-3 Monoclonal Antibody detects endogenous levels of IMP-3 protein.
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Gene Name:
IGF2BP3
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Protein Name:
Insulin-like growth factor 2 mRNA-binding protein 3
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Other Name:
IGF2BP3 ;
IMP3 ;
KOC1 ;
VICKZ3 ;
Insulin-like growth factor 2 mRNA-binding protein 3 ;
IGF2 mRNA-binding protein 3 ;
IMP-3 ;
IGF-II mRNA-binding protein 3 ;
KH domain-containing protein overexpressed in cancer ;
hKOC ;
VICKZ family member 3
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Database Link:
Organism Gene ID SwissProt
Human 10643; O00425;
Mouse Q9CPN8;
Background:
The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes. [provided by RefSeq, Jul 2008],
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Function:
Disease:Autoantibodies against IGF2BP3 are detected in sera from some patients with a variety of carcinomas.,Function:RNA-binding protein that act as a regulator of mRNA translation and stability. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binds to sequences in the 3'-UTR of CD44 mRNA.,similarity:Belongs to the RRM IMP/VICKZ family.,similarity:Contains 2 RRM (RNA recognition motif) domains.,similarity:Contains 4 KH domains.,subcellular location:Found in lamellipodia of the leading edge, in the perinuclear region, and beneath the plasma membrane. The subcytoplasmic localization is cell specific and regulated by cell contact and growth. Localized at the connecting piece and the tail of the spermatozoa. Colocalized with CD44 mRNA in RNP granules.,subunit:Homodimer and multimer.,tissue specificity:Expressed in fetal liver, fetal lung, fetal kidney, fetal thymus, fetal placenta, fetal follicles of ovary and gonocytes of testis, growing oocytes, spermatogonia and semen (at protein level). Expressed in cervix adenocarcinoma, in testicular, pancreatic and renal-cell carcinomas (at protein level). Expressed ubiquitously during fetal development at 8 and 14 weeks of gestation. Expressed in ovary, testis, brain, placenta, pancreatic cancer tissues and pancreatic cancer cell lines.,
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Cellular Localization:
Nucleus. Cytoplasm. Cytoplasm, P-body . Cytoplasm, Stress granule . Found in lamellipodia of the leading edge, in the perinuclear region, and beneath the plasma membrane. The subcytoplasmic localization is cell specific and regulated by cell contact and growth. Localized at the connecting piece and the tail of the spermatozoa. Colocalized with CD44 mRNA in RNP granules. In response to cellular stress, such as oxidative stress, recruited to stress granules.
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Tissue Expression:
Expressed in fetal liver, fetal lung, fetal kidney, fetal thymus, fetal placenta, fetal follicles of ovary and gonocytes of testis, growing oocytes, spermatogonia and semen (at protein level). Expressed in cervix adenocarcinoma, in testicular, pancreatic and renal-cell carcinomas (at protein level). Expressed ubiquitously during fetal development at 8 and 14 weeks of gestation. Expressed in ovary, testis, brain, placenta, pancreatic cancer tissues and pancreatic cancer cell lines.
show all
Catalog: YM0374
Size
Price
Status
Qty.
200μL
$600.00
3 weeks

0

100μL
$350.00
3 weeks

0

50μL
$210.00
3 weeks

0

Add to cart

Collected

Collect

Customized Service

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