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Catalog: YM0335
Size
Price
Status
Qty.
200μL
$600.00
3 weeks

0

100μL
$350.00
3 weeks

0

50μL
$210.00
3 weeks

0

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Main Information
Target

HPRT

Host Species

Mouse

Reactivity

Human

Applications

WB, ELISA

MW

25kD (Calculated)

Conjugate/Modification


Unmodified

Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
HPRT Monoclonal Antibody detects endogenous levels of HPRT protein.
Purification
Affinity purification
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
MW(Calculated)
25kD
Modification
Unmodified
Clonality
Monoclonal
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Antigen&Target Information
Immunogen:
Purified recombinant fragment of HPRT expressed in E. Coli.
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Specificity:
HPRT Monoclonal Antibody detects endogenous levels of HPRT protein.
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Gene Name:
HPRT1
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Protein Name:
Hypoxanthine-guanine phosphoribosyltransferase
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Other Name:
HPRT1 ;
HPRT ;
Hypoxanthine-guanine phosphoribosyltransferase ;
HGPRT ;
HGPRTase
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Database Link:
Organism Gene ID SwissProt
Human 3251; P00492;
Mouse P00493;
Background:
hypoxanthine phosphoribosyltransferase 1(HPRT1) Homo sapiens The protein encoded by this gene is a transferase, which catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate. This enzyme plays a central role in the generation of purine nucleotides through the purine salvage pathway. Mutations in this gene result in Lesch-Nyhan syndrome or gout.[provided by RefSeq, Jun 2009],
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Function:
Catalytic activity:GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate.,Catalytic activity:IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.,cofactor:Binds 2 magnesium ions per subunit. One of the ions does not make direct protein contacts.,Disease:Defects in HPRT1 are the cause of gout [MIM:300323]; also known as HPRT-related gout or Kelley-Seegmiller syndrome. Gout is characterized by partial enzyme activity and hyperuricemia.,Disease:Defects in HPRT1 are the cause of Lesch-Nyhan syndrome (LNS) [MIM:300322]. LNS is characterized by complete lack of enzymatic activity that results in hyperuricemia, choreoathetosis, mental retardation, and compulsive self-mutilation.,online information:Hypoxanthine-guanine phosphoribosyltransferase entry,pathway:Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.,similarity:Belongs to the purine/pyrimidine phosphoribosyltransferase family.,subunit:Homotetramer.,
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Cellular Localization:
Cytoplasm.
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Tissue Expression:
Brain,
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Research Areas:
>>Purine metabolism ;
>>Drug metabolism - other enzymes ;
>>Metabolic pathways ;
>>Nucleotide metabolism
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Catalog: YM0335
Size
Price
Status
Qty.
200μL
$600.00
3 weeks

0

100μL
$350.00
3 weeks

0

50μL
$210.00
3 weeks

0

Add to cart

Collected

Collect

Customized Service

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