Purified recombinant fragment of EphB1 (aa19-133) expressed in E. Coli.

EphB1 Monoclonal Antibody detects endogenous levels of EphB1 protein.

EPHB1

Ephrin type-B receptor 1

EPHB1 ;
ELK ;
EPHT2 ;
HEK6 ;
NET ;
Ephrin type-B receptor 1 ;
ELK ;
EPH tyrosine kinase 2 ;
EPH-like kinase 6 ;
EK6 ;
hEK6 ;
Neuronally-expressed EPH-related tyrosine kinase ;
NET ;
Tyrosine-protein kinase receptor EPH-2

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members. [provided by RefSeq, Jul 2008],

Catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,Function:Receptor for members of the ephrin-B family. Binds to ephrin-B1, -B2 and -B3. May be involved in cell-cell interactions in the nervous system.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,similarity:Contains 2 fibronectin type-III domains.,subunit:The ligand-activated form interacts with GRB2, GRB10 and NCK through their respective SH2 domains. The GRB10 SH2 domain binds EPHB1 through Tyr-928, while GRB2 binds residues within the catalytic domain. Interacts with EPHB6. The NCK SH2 domain binds EPHB1 through Tyr-594. Interacts with PRKCABP.,tissue specificity:Preferentially expressed in brain.,

Cell membrane ; Single-pass type I membrane protein . Early endosome membrane . Cell projection, dendrite .

Preferentially expressed in brain.

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