This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins.This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations inThis gene result in congenital tufting enteropathy. [provided by RefSeq, Dec 2008]
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Cellular Localization:
Lateral cell membrane ; Single-pass type I membrane protein . Cell junction, tight junction . Colocalizes with CLDN7 at the lateral cell membrane and tight junction. .