Catalog: YA0439
Size
Price
Status
Qty.
200μg
$600.00
3 weeks
0
100μg
$340.00
3 weeks
0
40μg
$190.00
3 weeks
0
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Collected
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Main Information
Target
GPR56
Reactivity
Human
Applications
ELISA, FC
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
ELISA 1:5000-100000
Formulation
Phosphate-buffered solution
Source
Camel, chimeric fusion of Nanobody (VHH) and mouse IgG1 Fc domain , recombinantly produced from 293F cell
Specificity
This recombinant monoclonal antibody can detects endogenous levels of GPR56 protein.
Purification
Recombinant Expression and Affinity purified
Storage
-15°C to -25°C/1 year(Avoid freeze / thaw cycles)
Concentration
Please check the information on the tube
Modification
Unmodified
Clone Number
PN0145
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Goat Anti Mouse IgG(H+L) (HRP)
RS0001
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Antigen&Target Information
Immunogen:
Purified recombinant Human GPR56
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Specificity:
This recombinant monoclonal antibody can detects endogenous levels of GPR56 protein.
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Gene Name:
ADGRG1 GPR56 TM7LN4 TM7XN1 UNQ540/PRO1083
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Protein Name:
Adhesion G-protein coupled receptor G1 (G-protein coupled receptor 56) (Protein TM7XN1) [Cleaved into: ADGRG1 N-terminal fragment (ADGRG1 NT) (GPR56 N-terminal fragment) (GPR56 NT) (GPR56(N)) (GPR56 extracellular subunit) (GPR56 subunit alpha); ADGRG1 C-terminal fragment (ADGRG1 CT) (GPR56 C-terminal fragment) (GPR56 CT) (GPR56(C)) (GPR56 seven-transmembrane subunit) (GPR56 7TM) (GPR56 subunit beta)]
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Other Name:
GPR56 ;
TM7LN4 ;
TM7XN1 ;
G-protein coupled receptor 56 ;
Protein TM7XN1 ;
GPR56 nanobody ;
TM7LN4 ;
TM7XN1 ;
G-protein coupled receptor 56 ;
Protein TM7XN1 ;
GPR56 nanobody ;
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Background:
This gene encodes a member of the G protein-coupled receptor family and regulates brain cortical patterning. The encoded protein binds specifically to transglutaminase 2, a component of tissue and tumor stroma implicated as an inhibitor of tumor progression. Mutations inThis gene are associated with a brain malformation known as bilateral frontoparietal polymicrogyria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
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Function:
Disease:Defects in GPR56 are the cause of bilateral frontoparietal polymicrogyria (BFPP) [MIM:606854]. BFPP is characterized by disorganized cortical lamination that is most severe in frontal cortex.,Could be involved in cell-cell interactions.,similarity:Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.,similarity:Contains 1 GPS domain.,tissue specificity:Widely distributed with highest levels found in thyroid gland, brain and heart. Expressed in a great number of tumor cells.,
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Cellular Localization:
Cell membrane ; Multi-pass membrane protein .; [ADGRG1 N-terminal fragment]: Secreted .; [ADGRG1 C-terminal fragment]: Membrane raft . Interaction with its ligand COL3A1 leads to the release of ADGRG1 NT from the membrane and triggers the association of ADGRG1 CT with lipid rafts. .
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Tissue Expression:
Detected in platelets (at protein level). Dysplastic nevi, radial growth phase primary melanomas, hematopoietic cells, tissue macrophages.
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Signaling Pathway
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Catalog: YA0439
Size
Price
Status
Qty.
200μg
$600.00
3 weeks
0
100μg
$340.00
3 weeks
0
40μg
$190.00
3 weeks
0
Add to cart
Collected
Collect
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