Purified recombinant Human CD269

This recombinant monoclonal antibody can detects endogenous levels of CD269/BCMA protein.

TNFRSF17 BCM BCMA

Tumor necrosis factor receptor superfamily member 17 (B-cell maturation protein) (CD antigen CD269)

TNFRSF17 ;
BCM ;
BCMA ;
Tumor necrosis factor receptor superfamily member 17 ;
B-cell maturation protein ;
CD269 ;
CD269 nanobody ;
BCMA nanobody ;

The protein encoded byThis gene is a member of the TNF-receptor superfamily.This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response.This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation.This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq, Jul 2008]

Disease:A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2.,Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.,similarity:Contains 1 TNFR-Cys repeat.,subcellular location:Perinuclear Golgi-like structures.,subunit:Associates with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6.,tissue specificity:Expressed in mature B-cells, but not in T-cells or monocytes.,

Cell membrane; Single-pass type III membrane protein. Endomembrane system; Single-pass type III membrane protein. Perinuclear Golgi-like structures.