Purified recombinant Human CD48

This recombinant monoclonal antibody can detects endogenous levels of CD48 protein.

CD48 BCM1 BLAST1

CD48 antigen (B-lymphocyte activation marker BLAST-1) (BCM1 surface antigen) (Leukocyte antigen MEM-102) (SLAM family member 2) (SLAMF2) (Signaling lymphocytic activation molecule 2) (TCT.1) (CD antigen CD48)

CD48 ;
BCM1 ;
BLAST1 ;
CD48 antigen ;
B-lymphocyte activation marker BLAST-1 ;
BCM1 surface antigen ;
Leukocyte antigen MEM-102 ;
TCT.1 ;
CD48 ;
CD48 nanobody ;

This gene encodes a member of the CD2 subfamily of immunoglobulin-like receptors which includes SLAM (signaling lymphocyte activation molecules) proteins. The encoded protein is found on the surface of lymphocytes and other immune cells, dendritic cells and endothelial cells, and participates in activation and differentiation pathways in these cells. The encoded protein does not have a transmembrane domain, however, but is held at the cell surface by a GPI anchor via a C-terminal domain which maybe cleaved to yield a soluble form of the receptor. Multiple transcript variants encoding different isoforms have been found forThis gene. [provided by RefSeq, Dec 2011]

Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,

Cell membrane ; Lipid-anchor, GPI-anchor . Secreted .

Detected on hematopoietic stem cells derived from umbilical cord blood (PubMed:2474813). Detected on lymph vessel endothelial cells, skin and tonsil (PubMed:23169771). Detected on peripheral blood monocytes (PubMed:154873). Detected on monocyte-derived dendritic cells (at protein level) (PubMed:1635286). Detected at low levels in spleen, placenta, liver (PubMed:952422). Expressed by activated T-cells, B-cells, monocytes and thymic epithelial cells (PubMed:7767). Isoform 1 and isoform 3 are detected in vein and artery endothelial cells, astrocytes, keratinocytes and artery smooth muscle cells (PubMed:15496415). Expressed by neurons in the brain. Restricted expression in tumor cell lines. Detected in highly metastasizing melanoma cell lines (PubMed:952422).