Synthesized peptide derived from human ACSL4

This antibody detects endogenous levels of ACSL4 at Human, Mouse,Rat

ACSL4 ACS4 FACL4 LACS4

ACSL4

Long-chain-fatty-acid--CoA ligase 4 ;
Long-chain acyl-CoA synthetase 4 ;
LACS 4 ;

The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the cognitive disability or Alport syndrome. Alternative splicing of this gene generates multiple transcript variants. [provided by RefSeq, Jan 2016]

Mitochondrion outer membrane ; Single-pass type III membrane protein . Peroxisome membrane ; Single-pass type III membrane protein . Microsome membrane ; Single-pass type III membrane protein . Endoplasmic reticulum membrane ; Single-pass type III membrane protein . Cell membrane .

>>Fatty acid biosynthesis ;
>>Fatty acid degradation ;
>>Metabolic pathways ;
>>Fatty acid metabolism ;
>>PPAR signaling pathway ;
>>Peroxisome ;
>>Ferroptosis ;
>>Thermogenesis ;
>>Adipocytokine signaling pathway