Catalog: YT5698
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
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Main Information
Target
Thrombospondin 2
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IF, ELISA
MW
130kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000.ELISA 1:10000.IF 1:50-200
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
Thrombospondin 2 Polyclonal Antibody detects endogenous levels of Thrombospondin 2 protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
130kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Thrombospondin 2 Rabbit pAb
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from the C-terminal region of human THBS2. AA range:1000-1050
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Specificity:
Thrombospondin 2 Polyclonal Antibody detects endogenous levels of Thrombospondin 2 protein.
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Gene Name:
THBS2
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Protein Name:
Thrombospondin-2
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Other Name:
THBS2 ;
TSP2 ;
Thrombospondin-2
TSP2 ;
Thrombospondin-2
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Background:
thrombospondin 2(THBS2) Homo sapiens The protein encoded by this gene belongs to the thrombospondin family. It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein has been shown to function as a potent inhibitor of tumor growth and angiogenesis. Studies of the mouse counterpart suggest that this protein may modulate the cell surface properties of mesenchymal cells and be involved in cell adhesion and migration. [provided by RefSeq, Jul 2008],
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Function:
Disease:Genetic variations in THBS2 may be a cause of susceptibility to lumbar disk herniation (LDH) [MIM:603932]. LDH is the predominant cause of low-back pain and unilateral leg pain.,Function:Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen, fibronectin, laminin and type V collagen.,similarity:Belongs to the thrombospondin family.,similarity:Contains 1 TSP C-terminal (TSPC) domain.,similarity:Contains 1 TSP N-terminal (TSPN) domain.,similarity:Contains 1 VWFC domain.,similarity:Contains 3 EGF-like domains.,similarity:Contains 3 TSP type-1 domains.,similarity:Contains 8 TSP type-3 repeats.,subunit:Homotrimer; disulfide-linked.,tissue specificity:High expression in invertebral disk tissue.,
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Cellular Localization:
extracellular region,basement membrane,extracellular matrix,platelet alpha granule,
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Tissue Expression:
High expression in invertebral disk tissue.
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Research Areas:
>>Phagosome ;
>>PI3K-Akt signaling pathway ;
>>Focal adhesion ;
>>ECM-receptor interaction ;
>>Malaria ;
>>Human papillomavirus infection
>>PI3K-Akt signaling pathway ;
>>Focal adhesion ;
>>ECM-receptor interaction ;
>>Malaria ;
>>Human papillomavirus infection
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Signaling Pathway
Cellular Processes >> Transport and catabolism >> Phagosome
Cellular Processes >> Cellular community - eukaryotes >> Focal adhesion
Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway
Environmental Information Processing >> Signaling molecules and interaction >> ECM-receptor interaction
Reference Citation({{totalcount}})
Catalog: YT5698
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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