Catalog: YT5580
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
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Collected
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Conjugated antibody
Main Information
Target
CD19
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
WB, FC, IHC, IF, ELISA
MW
61kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000; Flow Cyt 1:50-200; IHC 1:100-500; IF(paraffin section); ELISA 1:5000-20000
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
CD19 Polyclonal Antibody detects endogenous levels of CD19 protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
61kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from B-lymphocyte antigen CD19 at AA range: 191-240
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Specificity:
CD19 Polyclonal Antibody detects endogenous levels of CD19 protein.
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Gene Name:
CD19
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Protein Name:
B-lymphocyte antigen CD19
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Other Name:
CD19 ;
B-lymphocyte antigen CD19 ;
B-lymphocyte surface antigen B4 ;
Differentiation antigen CD19 ;
T-cell surface antigen Leu-12 ;
CD19
B-lymphocyte antigen CD19 ;
B-lymphocyte surface antigen B4 ;
Differentiation antigen CD19 ;
T-cell surface antigen Leu-12 ;
CD19
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Background:
Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. [provided by RefSeq, Jul 2008],
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Function:
Disease:Defects in CD19 are a cause of hypogammaglobulinemia [MIM:107265].,Function:Assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.,online information:CD19 mutation db,PTM:Phosphorylated on serine and threonine upon DNA damage, probably by ATM or ATR. Phosphorylated on tyrosine following B-cell activation.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Forms a complex with CD21, CD81 and CD225 in the membrane of mature B cells. Interacts with VAV. Interacts with GRB2 and SOS when phosphorylated on Tyr-348 and/or Tyr-378. Interacts with PLCG2 when phosphorylated on Tyr-409.,
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Cellular Localization:
Cell membrane ; Single-pass type I membrane protein . Membrane raft ; Single-pass type I membrane protein .
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Tissue Expression:
Detected on marginal zone and germinal center B cells in lymph nodes (PubMed:2463100). Detected on blood B cells (at protein level) (PubMed:2463100, PubMed:16672701).
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Research Areas:
>>PI3K-Akt signaling pathway ;
>>Hematopoietic cell lineage ;
>>B cell receptor signaling pathway ;
>>Epstein-Barr virus infection ;
>>Primary immunodeficiency
>>Hematopoietic cell lineage ;
>>B cell receptor signaling pathway ;
>>Epstein-Barr virus infection ;
>>Primary immunodeficiency
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YT5580
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
Conjugated antibody
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