Catalog: YT4454
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
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Collected
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Main Information
Target
Stat6
Host Species
Rabbit
Reactivity
Human, Mouse, Monkey
Applications
WB, IHC, IF, ELISA
MW
94kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000; IF 1:50-200
Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
Stat6 Polyclonal Antibody detects endogenous levels of Stat6 protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
94kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human STAT6. AA range:608-657
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Specificity:
Stat6 Polyclonal Antibody detects endogenous levels of Stat6 protein.
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Gene Name:
STAT6
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Protein Name:
Signal transducer and activator of transcription 6
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Other Name:
STAT6 ;
Signal transducer and activator of transcription 6 ;
IL-4 Stat
Signal transducer and activator of transcription 6 ;
IL-4 Stat
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Background:
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010],
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Function:
Function:Carries out a dual Function: signal transduction and activation of transcription. Involved in interleukin-4 signalling.,PTM:Tyrosine phosphorylated following stimulation by IL-4 and IL-3.,similarity:Belongs to the transcription factor STAT family.,similarity:Contains 1 SH2 domain.,subcellular location:Translocated into the nucleus in response to phosphorylation.,subunit:Forms a homodimer or a heterodimer with a related family member (By similarity). Interacts with NCOA1 via its C-terminal LXXLL motif.,
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Cellular Localization:
Cytoplasm. Nucleus. Translocated into the nucleus in response to phosphorylation.
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Tissue Expression:
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Research Areas:
>>Necroptosis ;
>>JAK-STAT signaling pathway ;
>>Th1 and Th2 cell differentiation ;
>>Th17 cell differentiation ;
>>Hepatitis B ;
>>Pathways in cancer ;
>>Inflammatory bowel disease
>>JAK-STAT signaling pathway ;
>>Th1 and Th2 cell differentiation ;
>>Th17 cell differentiation ;
>>Hepatitis B ;
>>Pathways in cancer ;
>>Inflammatory bowel disease
show all
Signaling Pathway
Cellular Processes >> Cell growth and death >> Necroptosis
Organismal Systems >> Immune system >> Th1 and Th2 cell differentiation
Organismal Systems >> Immune system >> Th17 cell differentiation
Human Diseases >> Cancer: overview >> Pathways in cancer
Human Diseases >> Immune disease >> Inflammatory bowel disease
Environmental Information Processing >> Signal transduction >> JAK-STAT signaling pathway
Reference Citation({{totalcount}})
Catalog: YT4454
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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