The antiserum was produced against synthesized peptide derived from human HTR2B. AA range:15-64

SR-2B Polyclonal Antibody detects endogenous levels of SR-2B protein.

HTR2B

5-hydroxytryptamine receptor 2B

HTR2B ;
5-hydroxytryptamine receptor 2B ;
5-HT-2B ;
5-HT2B ;
Serotonin receptor 2B

This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016],

Function:This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts with MPDZ.,tissue specificity:Detected in most peripheral organs. Only low expression levels were found in the brain.,

Cell membrane ; Multi-pass membrane protein . Cell junction, synapse, synaptosome .

Ubiquitous. Detected in liver, kidney, heart, pulmonary artery, and intestine. Detected at lower levels in blood, placenta and brain, especially in cerebellum, occipital cortex and frontal cortex.

>>Calcium signaling pathway ;
>>Neuroactive ligand-receptor interaction ;
>>Gap junction ;
>>Serotonergic synapse ;
>>Inflammatory mediator regulation of TRP channels