The antiserum was produced against synthesized peptide derived from human PIK3CG. AA range:881-930

PI 3-Kinase p110γ Polyclonal Antibody detects endogenous levels of PI 3-Kinase p110γ protein.

PIK3CG

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

PIK3CG ;
Phosphatidylinositol 4 ;
5-bisphosphate 3-kinase catalytic subunit gamma isoform ;
PI3-kinase subunit gamma ;
PI3K-gamma ;
PI3Kgamma ;
PtdIns-3-kinase subunit gamma ;
Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit

Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I catalytic subunit of PI3K. Like other class I catalytic subunits (p110-alpha p110-beta, and p110-delta), the encoded protein binds a p85 regulatory subunit to form PI3K. This gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2015],

Catalytic activity:ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate.,enzyme regulation:Activated by both the alpha and the beta-gamma G proteins.,Function:3-phosphorylates the cellular phosphoinositide PtdIns-4,5-biphosphate (PtdIns(4,5)P2) to produce PtdIns-3, 4,5-triiphosphate (PtdIns(3,4,5)P3). Links G-protein coupled receptor activation to the secondary messenger PtdIns(3,4,5)P3 production.,pathway:Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis.,similarity:Belongs to the PI3/PI4-kinase family.,similarity:Contains 1 PI3K/PI4K domain.,subunit:Heterodimer of a catalytic subunit (PIK3CG/p120) and a regulatory (PIK3R5a/p101) subunit.,tissue specificity:Pancreas, skeletal muscle, liver and heart.,

Cytoplasm . Cell membrane .

>>Inositol phosphate metabolism ;
>>Metabolic pathways ;
>>cGMP-PKG signaling pathway ;
>>Chemokine signaling pathway ;
>>Phospholipase D signaling pathway ;
>>PI3K-Akt signaling pathway ;
>>Adrenergic signaling in cardiomyocytes ;
>>Apelin signaling pathway ;
>>Platelet activation ;
>>Cholinergic synapse ;
>>Oxytocin signaling pathway ;
>>Salmonella infection ;
>>Toxoplasmosis ;
>>Kaposi sarcoma-associated herpesvirus infection