The antiserum was produced against synthesized peptide derived from human IL-1alpha. AA range:8-57

IL-1α Polyclonal Antibody detects endogenous levels of IL-1α protein.

IL1A

Interleukin-1 alpha

IL1A ;
IL1F1 ;
Interleukin-1 alpha ;
IL-1 alpha ;
Hematopoietin-1

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. [provided by RefSeq, Jul 2008],

Domain:The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.,Function:Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.,online information:Interleukin-1 entry,online information:The Singapore human mutation and polymorphism database,similarity:Belongs to the IL-1 family.,subcellular location:The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.,subunit:Monomer.,

Cytoplasm . Secreted . The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins. The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059). .

Lung,

>>MAPK signaling pathway ;
>>Cytokine-cytokine receptor interaction ;
>>Necroptosis ;
>>Cellular senescence ;
>>Osteoclast differentiation ;
>>Hematopoietic cell lineage ;
>>Non-alcoholic fatty liver disease ;
>>AGE-RAGE signaling pathway in diabetic complications ;
>>Type I diabetes mellitus ;
>>Alzheimer disease ;
>>Prion disease ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Pertussis ;
>>Leishmaniasis ;
>>Tuberculosis ;
>>Measles ;
>>Influenza A ;
>>Inflammatory bowel disease ;
>>Rheumatoid arthritis ;
>>Graft-versus-host disease ;
>>Fluid shear stress and atherosclerosis