The antiserum was produced against synthesized peptide derived from human GNAI3. AA range:31-80

Gα i-3 Polyclonal Antibody detects endogenous levels of Gα i-3 protein.

GNAI3

Guanine nucleotide-binding protein G(k) subunit alpha

GNAI3 ;
Guanine nucleotide-binding protein G ;
k ;
subunit alpha ;
G ;
i ;
alpha-3

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling pathways. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes an alpha subunit and belongs to the G-alpha family. Mutation in this gene, resulting in a gly40-to-arg substitution, is associated with auriculocondylar syndrome, and shown to affect downstream targets in the G protein-coupled endothelin receptor pathway. [provided by RefSeq, Jun 2012],

Function:Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(k) is the stimulatory G protein of receptor-regulated K(+) channels.,similarity:Belongs to the G-alpha family. G(i/o/t/z) subfamily.,subunit:G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts with GPSM1.,

Cytoplasm . Cell membrane ; Lipid-anchor . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Localizes in the centrosomes of interphase and mitotic cells. Detected at the cleavage furrow and/or the midbody. .

Liver,

>>Rap1 signaling pathway ;
>>cGMP-PKG signaling pathway ;
>>cAMP signaling pathway ;
>>Chemokine signaling pathway ;
>>Sphingolipid signaling pathway ;
>>Adrenergic signaling in cardiomyocytes ;
>>Axon guidance ;
>>Apelin signaling pathway ;
>>Gap junction ;
>>Platelet activation ;
>>Leukocyte transendothelial migration ;
>>Circadian entrainment ;
>>Retrograde endocannabinoid signaling ;
>>Glutamatergic synapse ;
>>Cholinergic synapse ;
>>Serotonergic synapse ;
>>GABAergic synapse ;
>>Dopaminergic synapse ;
>>Long-term depression ;
>>Progesterone-mediated oocyte maturation ;
>>Estrogen signaling pathway ;
>>Melanogenesis ;
>>Oxytocin signaling pathway ;
>>Regulation of lipolysis in adipocytes ;
>>Renin secretion ;
>>Relaxin signaling pathway ;
>>Parathyroid hormone synthesis, secretion and action ;
>>Cushing syndrome ;
>>Growth hormone synthesis, secretion and action ;
>>Gastric acid secretion ;
>>Parkinson disease ;
>>Cocaine addiction ;
>>Morphine addiction ;
>>Alcoholism ;
>>Pertussis ;
>>Chagas disease ;
>>Toxoplasmosis ;
>>Human cytomegalovirus infection ;
>>Human immunodeficiency virus 1 infection ;
>>Pathways in cancer ;
>>Chemical carcinogenesis - receptor activation