The antiserum was produced against synthesized peptide derived from human TNFRSF10A. AA range:401-450

DR4 Polyclonal Antibody detects endogenous levels of DR4 protein.

TNFRSF10A

Tumor necrosis factor receptor superfamily member 10A

TNFRSF10A ;
APO2 ;
DR4 ;
TRAILR1 ;
Tumor necrosis factor receptor superfamily member 10A ;
Death receptor 4 ;
TNF-related apoptosis-inducing ligand receptor 1 ;
TRAIL receptor 1 ;
TRAIL-R1 ;
CD antigen CD261

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq, Jul 2008],

Function:Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.,similarity:Contains 1 death domain.,similarity:Contains 3 TNFR-Cys repeats.,subunit:Can interact with TRADD and RIP. Interacts with ARAP1.,tissue specificity:Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K562 erythroleukemia cells, MCF7 breast carcinoma cells and activated T-cells.,

Cell membrane ; Single-pass type I membrane protein . Membrane raft . Cytoplasm, cytosol . Palmitoylation is required for association with membranes. .

Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells.

>>Cytokine-cytokine receptor interaction ;
>>Viral protein interaction with cytokine and cytokine receptor ;
>>p53 signaling pathway ;
>>Apoptosis ;
>>Necroptosis ;
>>Natural killer cell mediated cytotoxicity ;
>>Pathogenic Escherichia coli infection ;
>>Salmonella infection ;
>>Influenza A ;
>>Lipid and atherosclerosis