Catalog: YT0387
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
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Main Information
Target
ATF-3
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC, IF, ELISA
MW
21kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000; IHC 1:100-500; IF/ICC1:100-500; ELISA 1:5000-20000
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
ATF-3 Polyclonal Antibody detects endogenous levels of ATF-3 protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
21kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human ATF3. AA range:131-180
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Specificity:
ATF-3 Polyclonal Antibody detects endogenous levels of ATF-3 protein.
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Gene Name:
ATF3
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Protein Name:
Cyclic AMP-dependent transcription factor ATF-3
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Other Name:
ATF3 ;
Cyclic AMP-dependent transcription factor ATF-3 ;
cAMP-dependent transcription factor ATF-3 ;
Activating transcription factor 3
Cyclic AMP-dependent transcription factor ATF-3 ;
cAMP-dependent transcription factor ATF-3 ;
Activating transcription factor 3
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Database Link:
Background:
activating transcription factor 3(ATF3) Homo sapiens This gene encodes a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. This gene is induced by a variety of signals, including many of those encountered by cancer cells, and is involved in the complex process of cellular stress response. Multiple transcript variants encoding different isoforms have been found for this gene. It is possible that alternative splicing of this gene may be physiologically important in the regulation of target genes. [provided by RefSeq, Apr 2011],
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Function:
Function:This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters.,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. ATF subfamily.,similarity:Contains 1 bZIP domain.,subunit:Binds DNA as a homodimer or a heterodimer.,
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Cellular Localization:
Nucleus .
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Tissue Expression:
Amygdala,Brain,Cerebellum,Muscle,
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Reference Citation({{totalcount}})
Catalog: YT0387
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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