The antiserum was produced against synthesized peptide derived from human AhR. AA range:2-51

Ah Receptor Polyclonal Antibody detects endogenous levels of Ah Receptor protein.

AHR BHLHE76

Aryl hydrocarbon receptor

AHR ;
BHLHE76 ;
Aryl hydrocarbon receptor ;
Ah receptor ;
AhR ;
Class E basic helix-loop-helix protein 76 ;
bHLHe76 ;
AHRR ;
BHLHE77 ;
KIAA1234 ;
Aryl hydrocarbon receptor repressor ;
AhR repressor ;
AhRR ;
Class E basic helix-loop-helix protein 77 ;
bHL

The protein encoded by this gene is a ligand-activated helix-loop-helix transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Before ligand binding, the encoded protein is sequestered in the cytoplasm; upon ligand binding, this protein moves to the nucleus and stimulates transcription of target genes. [provided by RefSeq, Sep 2015],

Function:Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues.,induction:Induced or repressed by TGF-beta and dioxin in a cell-type specific fashion. Repressed by cAMP, retinoic acid, and TPA.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,similarity:Contains 1 PAC (PAS-associated C-terminal) domain.,similarity:Contains 2 PAS (PER-ARNT-SIM) domains.,subcellular location:Initially cytoplasmic; upon binding with ligand and interaction with a HSP90, it translocates to the nucleus.,subunit:Binds MYBBP1A (By similarity). Efficient DNA binding requires dimerization with another bHLH protein. In the nucleus, heterodimer of AHR and ARNT. Interacts with coactivators including SRC-1, RIP140 and NOCA7, and with the corepressor SMRT. Interacts with NEDD8 and IVNS1ABP.,tissue specificity:Expressed in all tissues tested including blood, brain, heart, kidney, liver, lung, pancreas and skeletal muscle.,

Cytoplasm . Nucleus . Initially cytoplasmic; upon binding with ligand and interaction with a HSP90, it translocates to the nucleus. .

Expressed in all tissues tested including blood, brain, heart, kidney, liver, lung, pancreas and skeletal muscle. Expressed in retinal photoreceptors (PubMed:29726989).

>>Th17 cell differentiation ;
>>Cushing syndrome ;
>>Chemical carcinogenesis - receptor activation ;
>>Chemical carcinogenesis - reactive oxygen species