Synthetic Peptide of CaMKIIβ/γ/δ (Phospho Thr287)

CaMKIIβ/γ/δ (Phospho Thr287) protein detects endogenous levels of CaMKIIβ/γ/δ (Phospho Thr287)

CAMK2B

Calcium/calmodulin-dependent protein kinase type II subunit beta

CAMK2B ;
CAM2 ;
CAMK2 ;
CAMKB ;
Calcium/calmodulin-dependent protein kinase type II subunit beta ;
CaM kinase II subunit beta ;
CaMK-II subunit beta ;
CAMK2G ;
CAMK ;
CAMK-II ;
CAMKG ;
Calcium/calmodulin-dependent protein kinase type II subunit gamma ;

The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014],

Alternative products:The variable region of the CAMK2B protein is encoded by at least 7 exons (V1 to V7). Alternative splicing within this region gives rise to CAMK2B isoforms,Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Autophosphorylation of CAMK2 plays an important role in the regulation of the kinase activity.,Function:CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses, it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.,similarity:Contains 1 protein kinase domain.,subunit:CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Interacts with SYNGAP1 and CAMK2N2 (By similarity). Interacts with MPDZ.,tissue specificity:Widely expressed. Expressed in adult and fetal brain. Expression is slightly lower in fetal brain.,

Cytoplasm, cytoskeleton . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Sarcoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell junction, synapse . In slow-twitch muscle, evenly distributed between longitudinal SR and junctional SR.

>>ErbB signaling pathway ;
>>Calcium signaling pathway ;
>>cAMP signaling pathway ;
>>HIF-1 signaling pathway ;
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>>Axon guidance ;
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>>Oxytocin signaling pathway ;
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>>Parkinson disease ;
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>>Glioma ;
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