Synthesized peptide derived from human RSK3 (Phospho Thr353)

This antibody detects endogenous levels of Human,Mouse RSK3 (Phospho Thr353).The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):EFtARtPT

RPS6KA2 MAPKAPK1C RSK3

RSK3 (Phospho Thr353)

Ribosomal protein S6 kinase alpha-2 ;
S6K-alpha-2 ;
90 kDa ribosomal protein S6 kinase 2 ;
p90-RSK 2 ;
p90RSK2 ;
MAP kinase-activated protein kinase 1c ;
MAPK-activated protein kinase 1c ;
MAPKAP kinase 1c ;
MAPKAPK-1c ;
Ribosomal S6 kinase 3 ;
RSK-3 ;
pp90RSK3 ;

catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by multiple phosphorylations on threonine and serine residues.,function:Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.,PTM:Autophosphorylated on Ser-377, as part of the activation process.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 2 protein kinase domains.,subunit:Forms a complex with either ERK1 or ERK2 in quiescent cells. Transiently dissociates following mitogenic stimulation.,tissue specificity:Expressed in many tissues. Highest expression in lung and skeletal muscle.,

protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, intracellular signaling cascade, protein kinase cascade, phosphorylation,

Nucleus . Cytoplasm .

Widely expressed with higher expression in lung, skeletal muscle, brain, uterus, ovary, thyroid and prostate.

>>MAPK signaling pathway ;
>>Oocyte meiosis ;
>>mTOR signaling pathway ;
>>Thermogenesis ;
>>Long-term potentiation ;
>>Neurotrophin signaling pathway ;
>>Progesterone-mediated oocyte maturation ;
>>Insulin resistance ;
>>Yersinia infection ;
>>Chemical carcinogenesis - receptor activation