The antiserum was produced against synthesized peptide derived from human FLT3 around the phosphorylation site of Tyr599. AA range:565-614

Phospho-FLT3 (Y599) Polyclonal Antibody detects endogenous levels of FLT3 protein only when phosphorylated at Y599.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):YEyDL

FLT3

Receptor-type tyrosine-protein kinase FLT3

FLT3 ;
CD135 ;
FLK2 ;
STK1 ;
Receptor-type tyrosine-protein kinase FLT3 ;
FL cytokine receptor ;
Fetal liver kinase-2 ;
FLK-2 ;
Fms-like tyrosine kinase 3 ;
FLT-3 ;
Stem cell tyrosine kinase 1 ;
STK-1 ;
CD antigen CD135

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jan 2015],

Catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,Function:Receptor for the FL cytokine. Has a tyrosine-protein kinase activity.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with FIZ1 following ligand activation.,tissue specificity:Bone marrow cells.,

Membrane; Single-pass type I membrane protein. Endoplasmic reticulum lumen. Constitutively activated mutant forms with internal tandem duplications are less efficiently transported to the cell surface and a significant proportion is retained in an immature form in the endoplasmic reticulum lumen. The activated kinase is rapidly targeted for degradation.

>>MAPK signaling pathway ;
>>Ras signaling pathway ;
>>PI3K-Akt signaling pathway ;
>>Hematopoietic cell lineage ;
>>Pathways in cancer ;
>>Transcriptional misregulation in cancer ;
>>Acute myeloid leukemia ;
>>Central carbon metabolism in cancer