Synthesized peptide derived from part region of human protein

HLAG Polyclonal Antibody detects endogenous levels of protein.

HLA-G HLA-6.0 HLAG

HLA class I histocompatibility antigen, alpha chain G (HLA G antigen) (MHC class I antigen G)

HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008],

Function:Involved in the presentation of foreign antigens to the immune system.,similarity:Belongs to the MHC class I family.,similarity:Contains 1 Ig-like C1-type (immunoglobulin-like) domain.,subunit:Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).,tissue specificity:Expression of HLAG seems to be restricted to eye cells and tissue.,

[Isoform 1]: Cell membrane ; Single-pass type I membrane protein . Endoplasmic reticulum membrane . Early endosome membrane .; [Soluble HLA class I histocompatibility antigen, alpha chain G]: Secreted .; [Isoform 2]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 3]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 4]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 5]: Secreted . Early endosome .; [Isoform 6]: Secreted .; [Isoform 7]: Secreted .; Cell projection, filopodium membrane . HLA-G trogocytosis from extravillous trophoblast's filopodia occurs in the majority of decidual NK cells. .

Expressed in adult eye (PubMed:1570318). Expressed in immune cell subsets including monocytes, myeloid and plasmacytoid dendritic cells and regulatory T cells (Tr1)(at protein level) (PubMed:20448110). Secreted by follicular dendritic cell and follicular helper T cells (PubMed:24453251). Isoform 5: Detected in physiological fluids including amniotic fluid and serum (PubMed:11137219). Isoform 7: Expressed in placenta, amniotic membrane, skin cord blood and peripheral blood mononuclear cells (PubMed:11137219).

>>Endocytosis ;
>>Phagosome ;
>>Cellular senescence ;
>>Cell adhesion molecules ;
>>Antigen processing and presentation ;
>>Type I diabetes mellitus ;
>>Human cytomegalovirus infection ;
>>Human papillomavirus infection ;
>>Human T-cell leukemia virus 1 infection ;
>>Kaposi sarcoma-associated herpesvirus infection ;
>>Herpes simplex virus 1 infection ;
>>Epstein-Barr virus infection ;
>>Human immunodeficiency virus 1 infection ;
>>Viral carcinogenesis ;
>>Autoimmune thyroid disease ;
>>Allograft rejection ;
>>Graft-versus-host disease ;
>>Viral myocarditis