Synthesized peptide derived from human protein . at AA range: 270-350

ACM3 Polyclonal Antibody detects endogenous levels of protein.

CHRM3

Muscarinic acetylcholine receptor M3

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue. [provided by RefSeq, Jul 2008],

Function:The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.,similarity:Belongs to the G-protein coupled receptor 1 family.,

Cell membrane ; Multi-pass membrane protein . Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein . Basolateral cell membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein . Colocalizes with TMEM147 in the endoplasmic reticulum (ER) membrane. TMEM147 impairs its trafficking to the cell membrane leading to its retention in the ER membrane. .

>>Calcium signaling pathway ;
>>Neuroactive ligand-receptor interaction ;
>>Cholinergic synapse ;
>>Taste transduction ;
>>Regulation of actin cytoskeleton ;
>>Insulin secretion ;
>>Salivary secretion ;
>>Gastric acid secretion ;
>>Pancreatic secretion ;
>>Alzheimer disease ;
>>Pathways of neurodegeneration - multiple diseases