Synthesized peptide derived from part region of human protein

CR3L1 Polyclonal Antibody detects endogenous levels of protein.

CREB3L1 OASIS PSEC0238

Cyclic AMP-responsive element-binding protein 3-like protein 1 (cAMP-responsive element-binding protein 3-like protein 1) (Old astrocyte specifically-induced substance) (OASIS) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 1]

The protein encoded by this gene is normally found in the membrane of the endoplasmic reticulum (ER). However, upon stress to the ER, the encoded protein is cleaved and the released cytoplasmic transcription factor domain translocates to the nucleus. There it activates the transcription of target genes by binding to box-B elements. [provided by RefSeq, Jun 2013],

Function:Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Specifically involved in ER-stress response in astrocytes in the central nervous system (By similartity). May play a role in gliosis. In vitro, binds to box-B element, cAMP response element (CRE) and CRE-like sequences, and activates transcription through box-B element but not through CRE.,PTM:Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage is performed sequentially by site-1 and site-2 proteases (PS1 and PS2) and is triggered by translocation to the Golgi apparatus.,similarity:Belongs to the bZIP family. ATF subfamily.,similarity:Contains 1 bZIP domain.,subcellular location:Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.,tissue specificity:Ubiquitously expressed with high levels in pancreas and prostate. Expressed at relatively lower levels in brain.,

Endoplasmic reticulum membrane ; Single-pass type II membrane protein. ER membrane resident protein. Upon ER stress, translocated to the Golgi apparatus where it is cleaved. The cytosolic N-terminal fragment (processed cyclic AMP-responsive element-binding protein 3-like protein 1) is transported into the nucleus. .; [Processed cyclic AMP-responsive element-binding protein 3-like protein 1]: Nucleus . Upon ER stress, transported into the nucleus. .

>>cGMP-PKG signaling pathway ;
>>cAMP signaling pathway ;
>>PI3K-Akt signaling pathway ;
>>AMPK signaling pathway ;
>>Longevity regulating pathway ;
>>Adrenergic signaling in cardiomyocytes ;
>>TNF signaling pathway ;
>>Thermogenesis ;
>>Cholinergic synapse ;
>>Dopaminergic synapse ;
>>Insulin secretion ;
>>Estrogen signaling pathway ;
>>Melanogenesis ;
>>Thyroid hormone synthesis ;
>>Glucagon signaling pathway ;
>>Aldosterone synthesis and secretion ;
>>Relaxin signaling pathway ;
>>Cortisol synthesis and secretion ;
>>Parathyroid hormone synthesis, secretion and action ;
>>Insulin resistance ;
>>Cushing syndrome ;
>>Growth hormone synthesis, secretion and action ;
>>Vasopressin-regulated water reabsorption ;
>>Huntington disease ;
>>Prion disease ;
>>Cocaine addiction ;
>>Amphetamine addiction ;
>>Alcoholism ;
>>Hepatitis B ;
>>Human cytomegalovirus infection ;
>>Human papillomavirus infection ;
>>Human T-cell leukemia virus 1 infection ;
>>Viral carcinogenesis ;
>>Chemical carcinogenesis - receptor activation ;
>>Prostate cancer