Synthesized peptide derived from human protein . at AA range: 30-110

ITA11 Polyclonal Antibody detects endogenous levels of protein.

ITGA11 MSTP018

Integrin alpha-11

This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein contains an I domain, is expressed in muscle tissue, dimerizes with beta 1 integrin in vitro, and appears to bind collagen in this form. Therefore, the protein may be involved in attaching muscle tissue to the extracellular matrix. Alternative transcriptional splice variants have been found for this gene, but their biological validity is not determined. [provided by RefSeq, Jul 2008],

developmental stage:Strongly up-regulated in differentiating fetal muscle cells (in vitro).,Domain:The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.,Function:Integrin alpha-11/beta-1 is a receptor for collagen.,similarity:Belongs to the integrin alpha chain family.,similarity:Contains 1 VWFA domain.,similarity:Contains 7 FG-GAP repeats.,subunit:Heterodimer of an alpha and a beta subunit. Alpha-11 associates with beta-1. Interacts with RAB21.,tissue specificity:According PubMed:10464311 highest levels in uterus and heart, intermediate levels in skeletal muscle and intermediate to low levels in pancreas, kidney and placenta. According to PubMed:10486209 also found in brain, colon, lung, small intestine, stomach, testis, salivary glands, thyroid glands and prostate. Very low levels in peripheral blood lymphocytes, fetal brain and fetal liver.,

Membrane; Single-pass type I membrane protein.

According to PubMed:10464311, highest levels of expression in uterus and heart, intermediate levels in skeletal muscle and intermediate to low levels in pancreas, kidney and placenta. According to PubMed:10486209, also found in brain, colon, lung, small intestine, stomach, testis, salivary glands, thyroid glands and prostate. Very low levels in peripheral blood lymphocytes, fetal brain and fetal liver.

>>PI3K-Akt signaling pathway ;
>>Focal adhesion ;
>>ECM-receptor interaction ;
>>Regulation of actin cytoskeleton ;
>>Human papillomavirus infection ;
>>Hypertrophic cardiomyopathy ;
>>Arrhythmogenic right ventricular cardiomyopathy ;
>>Dilated cardiomyopathy